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KMID : 0043320090320111643
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Archives of Pharmacal Research
2009 Volume.32 No. 11 p.1643 ~ p.1649
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Antinociceptive Profiles and Mechanisms of Orally Administered Vanillin in the Mice
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Suh Hong-Won
Park Soo-Hyun
Sim Yun-Beom
Choi Seung-Min
Seo Young-Jun
Kwon Min-Soo
Lee Jin-Koo
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Abstract
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In the present study, the antinociceptive profiles of vanillin were examined in ICR mice. Vanillin administered orally (from 1 to 10 mg/kg) showed an antinociceptive effect in a dosedependent manner as measured in the acetic acid-induced writhing test. Duration of antinociceptive action of vanillin maintained at least for 30 min. But, the cumulative response time of nociceptive behaviors induced by a subcutaneous (s.c.) formalin injection, intrathecal (i.t.) substance P (0.7 μg) or glutamate (20 μg) injection was not affected by vanillin. Intraperitoneal (i.p.) pretreatment with yohimbine (α2-adrenergic receptor antagonist) or naloxone (opioid receptor antagonist) attenuated antinociceptive effect induced by vanillin in the writhing test. However, phentolamine (α1-adrenergic receptor antagonist) or methysergide (5-HT serotonergic receptor antagonist) did not affect antinociception induced by vanillin in the writhing test. Our results suggest that vanillin exerts a selective antinociceptive property in the acetic acidinduced visceral inflammatory pain model. Furthermore, this antinociceptive effect of vanillin may be mediated by α2-adrenergic and opioid receptors, but not α1-adrenergic and serotonergic receptors.
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KEYWORD
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Vanillin, Antinociception, Inflammatory pain, α2 adrenoceptor, Opioid receptor
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